(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
DG172 (dihydrochloride)
CAS: 1361504-77-9
Molecular Formula: C20H21BrClN3
(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride - Names and Identifiers
(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride - Physico-chemical Properties
| Molecular Formula | C20H21BrClN3 |
| Molar Mass | 418.76 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| In vitro study | DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC 50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC 50 , 9.5 nM). DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b + /Gr1 + granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells. |
(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.197 ml | 10.984 ml | 21.967 ml |
| 5 mM | 0.439 ml | 2.197 ml | 4.393 ml |
| 10 mM | 0.22 ml | 1.098 ml | 2.197 ml |
| 5 mM | 0.044 ml | 0.22 ml | 0.439 ml |
Last Update：2024-01-02 23:10:35
(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride - Reference Information
| biological activity | DG172 dihydroxy chloride is a selective PPAR β/δ antagonist with an IC50 value of 27 nM. |
Last Update：2024-04-10 22:29:15
![(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride](http://res.chembk.com/assets/str/2d/1/13/1361504-77-9.png)
Supplier List
Spot supply
Product Name: DG172 (dihydrochloride) Visit Supplier Webpage Request for quotationCAS: 1361504-77-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: DG172 (dihydrochloride) Visit Supplier Webpage Request for quotationCAS: 1361504-77-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History